Peptide detail

HGH Fragment 176-191

HGH Fragment 176-191 is a synthetic peptide corresponding to amino acids 176-191 of the human growth hormone (hGH) beta chain. Its primary mechanism of action is believed to be the selective stimulation of lipolysis (fat breakdown) and inhibition of lipogenesis (fat accumulation) in adipocytes, without exhibiting the full spectrum of hGH's insulin-like growth factor 1 (IGF-1)-mediated effects on growth or blood sugar. This selectivity is attributed to its interaction with specific fat cell receptors, promoting hormone-sensitive lipase activity and enhancing the breakdown of triglycerides into free fatty acids. In research contexts, it is primarily used as a tool to study localized fat metabolism, adipose tissue biology, and potential therapeutic avenues for obesity and metabolic syndrome. Key characteristics include its short sequence (16 amino acids), modified N-terminus (often acetylated for stability), and its reputation for targeting stubborn adipose deposits without significant systemic anabolic or hyperglycemic side effects associated with full-length hGH.