Peptide detail

Melanotan I

Melanotan I (also known as Afamelanotide) is a synthetic linear tridecapeptide analog of α-melanocyte-stimulating hormone (α-MSH). Its primary mechanism of action is agonist activity at the melanocortin 1 receptor (MC1R), which stimulates melanogenesis and increases eumelanin production in skin melanocytes, leading to skin pigmentation without direct UV exposure. Key characteristics include its stability against enzymatic degradation compared to α-MSH and its ability to induce tanning. Primary research uses have focused on photoprotection for individuals with erythropoietic protoporphyria (EPP) and other photosensitivity disorders, with clinical applications exploring its potential in reducing phototoxicity. Research also investigates its role in modulating inflammation and oxidative stress.