Peptide detail

Melanotan II

Melanotan II is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). Its primary mechanism of action is non-selective agonism of melanocortin receptors (MCRs), with high affinity for MC1R, MC3R, MC4R, and MC5R. Activation of MC1R on melanocytes stimulates eumelanin production, leading to skin pigmentation without UV exposure. Its action on MC4R in the central nervous system is associated with appetite suppression, increased libido, and potential erectile function modulation. In research contexts, it has been primarily investigated for its potential in photoprotection against UV-induced damage, as a probe for studying melanocortin receptor signaling pathways, and for exploring treatments for sexual dysfunction and obesity. Key characteristics include its cyclic structure (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2), which enhances metabolic stability compared to linear peptides, and its ability to induce rapid and prolonged tanning. It is a research chemical with no approved medical use.