Peptide detail

PT-141

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). Its primary mechanism of action is as a potent agonist of melanocortin receptors, with high selectivity for the MC4R and MC3R subtypes in the central nervous system. Activation of these receptors, particularly in hypothalamic pathways, modulates dopaminergic signaling and influences sexual arousal and desire, independent of the gonadal steroid hormone pathway. Its key characteristics include its subcutaneously administered, non-hormonal nature and ability to cross the blood-brain barrier. Primary research uses have focused on treating hypoactive sexual desire disorder (HSDD) and female sexual arousal disorder (FSAD), with investigations into its pro-sexual effects and potential utility in addressing sexual dysfunction associated with antidepressants. It is distinct from phosphodiesterase type 5 inhibitors as it acts centrally on desire rather than peripherally on erectile function.